Lions vs Bills Odds
Detroit Lions at Buffalo Bills — NFL Week 2
Kickoff Thursday, September 17 at 7:15 PM CT · lines updated 2026-08-22 · 1 books quoting
Best available price per side
| Market | Side | Best price | Book |
|---|---|---|---|
| Spread | Buffalo Bills -3 | -110 | DraftKings |
| Spread | Detroit Lions +3 | -110 | DraftKings |
| Total | Over 52.5 | -110 | DraftKings |
| Total | Under 52.5 | -110 | DraftKings |
| Moneyline | Detroit Lions | +130 | DraftKings |
| Moneyline | Buffalo Bills | -155 | DraftKings |
Prices are the best available across DraftKings, FanDuel, BetMGM and Fanatics at the time of the last update. Moneylines at -200 or worse are omitted by house rule.
How to read this page
Every number above is the best price a bettor could get on that side, and the book posting it. Books move independently, so the best spread and the best total on the same game often sit at different books. Player props are tracked on paper first and are not surfaced as rated plays until they clear our promotion gate.
21+. For entertainment purposes only. Not financial advice.